First live birth following dead donor transplant

First live birth following dead donor transplant

Previous attempts in the Czech Republic, Turkey and the USA have failed.

The baby girl was born almost a year ago to a 32-year-old woman who wasn't born with a uterus, according to the report detailed in the medical journal Lancet on Tuesday.

Writing in the Lancet, Ejzenberg and colleagues report how they removed a womb from a 45-year-old woman who had died from a burst blood vessel in the brain and who had previously given birth three times. After almost 36 weeks a baby girl weighing 2.5 kilograms (about six pounds) was delivered via caesarean section.

"I'd have to say it's in the pipelines but there are easier ways to have children like finding a surrogate or adopting", she said. About a dozen babies have now been born from uteruses provided by living donors-usually the recipient's mother, sister or friend-out of about 50 attempts worldwide. Falcone said the fact that the transplant was successful after the uterus was preserved in ice for almost eight hours demonstrated how resilient the uterus is.

In the past few years surgeons have attempted 10 other womb transplants from deceased donors in the US, Czech Republic and Turkey, but none have been successful.

He said any doubts he had about the potential importance of uterus transplants were erased after meeting the mother of the first baby born after a live donor uterus transplant.

"Our results provide a proof-of-concept for a new option for women with uterine infertility", said Dani Ejzenberg, a doctor at the teaching hospital of the University of Sao Paulo.

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"The numbers of people willing and committed to donate organs upon their own deaths are far larger than those of live donors, offering a much wider potential donor population", said Dr Ejzenberg in a statement about the procedure.

This isn't the first baby born to a woman with a uterine transplant-several have been born in Sweden, the US, and Brazil to women who received uterine transplants from live donors. But any donor has to undergo a radical hysterectomy, a lengthy procedure (it once took 10 to 12 hours, and is now four to six hours) that comes with its own risks and recovery period. On the other hand, the researchers state that transplants from deceased donors might have some benefits over donations from live donors. But the researchers believe a key factor could have been the timing. He also tried the procedure on a second Brazilian woman, but she had to have the uterus removed two days after the operation because of complications.

The fertilised eggs were implanted after seven months.

Uterine transplants from living donors have occurred before. Seven months later, the team transferred an IVF-created embryo into the womb. Each organ type triggers a different level of immune response, she says, and because the uterus is only needed for a short time-rather than a lifetime, as with a kidney or heart-patients may be able to get away with less medication.

Since then, he has participated in a live donor surgery, during which an identical twin donated her uterus to her sister, who was born without one.

It detailed how five months after the transplant, the uterus showed no signs of rejection, ultrasound scans were normal, and the recipient was having regular menstruation.