Medicine

Hormone therapy will replace chemotherapy for most breast cancer treatment

Hormone therapy will replace chemotherapy for most breast cancer treatment

"With the results of this groundbreaking study, we can now safely avoid chemotherapy in about 70 per cent of patients who are diagnosed with the most common form of breast cancer".

The findings were released at the American Society of Clinical Oncology (ASCO) meeting in Chicago, the world's largest annual cancer conference.

Women 50 or younger can avoid chemo if their scores are lower than 16, said lead author Joseph Sparano, associate director for clinical research at the Albert Einstein Cancer Center in NY.

The life of a woman with terminal breast cancer has been saved by a pioneering new therapy, say U.S. researchers. Many women think "if I don't get chemotherapy I'm going to die, and if I get chemo I'm going to be cured", but the study shows there's a sliding scale of benefits and sometimes none at all, he said.

After enrolling for new trial in 2015, doctors in the USA adopted an experimental approach combining two different forms of immunotherapy after conventional hormone treatments and chemotherapy failed.

For the TAILORx study, scientists recruited over 10,000 women with the most common type of breast cancer, called oestrogen-receptor positive (ER+) HER2-negative breast cancer.

The treatment involves a highly personalized approach and a patient's tumor is genetically analyzed to "identify the rare changes that might make the cancer visible to the immune system".

A sample of the tumour is tested after surgery for 21 genetic markers, which indicate if it could grow and spread. "Not only did these trials provide great relief for women in Ireland who participated and avoided three months of chemotherapy, it delivered considerable cost savings to the HSE", Ms Mulroe noted.

Merkel comments on Eurozone reform show move
In another nod to Macron, Merkel said she had a "positive view" of his joint European military intervention force. Merkel confirmed she could envision future British participation in European defense intervention forces.

Ms Perkins had 62 mutations in her tumour cells.

"Oncologists have been getting much smarter about dialing back treatment so that it doesn't do more harm than good", Steven Katz, a University of MI researcher who examines medical decision-making, told the Washington Post.

The researchers noted one caveat to the findings, however: Women who were either premenopausal and/or younger than 50 and fell in the higher part of the medium-risk range (scores of 16 to 25) may have experienced a slight benefit from chemotherapy. Such patients have been in "the gray zone, and we haven't known what to tell them", Kurian said. Patients with scores between 11 and 25, though, represent an uncertainty. Women with low risk scores - those below 10 - don't need chemotherapy after surgery, and instead can be treated with hormone therapy, previous studies have found.

Women aged 50 or younger were the notable exception.

"If confirmed in a larger study, it promises to further extend the reach of this T-cell therapy to a broader spectrum of cancers".

When she was selected for the trial in 2015, the Florida woman "had tennis ball-sized tumours in her liver and secondary cancers throughout her body". "With your help, we can continue to support a better informed local community and a healthier democracy for another 30 years". Treatment options include estrogen-blocking drugs along with doses of chemotherapy to lower the risk of recurrence. About 84 percent also had no signs of cancer, so chemo treatment had no impact.

Research has shown that Oncotype Dx and other tests, including Breast Cancer Index and EndoPredict, vary in accuracy, particularly when predicting the long-term risk of someone's cancer coming back. Since its establishment in 1996, over 15,000 people have participated in more than 350 cancer trials.


  • Facebook 'not aware of any abuse' of data by phone makers

    Facebook 'not aware of any abuse' of data by phone makers

    Such integrations were perhaps necessary at a time when smartphones didn't have adequate specifications to run Facebook apps. From 2009 to 2012, she was an award-winning syndicated columnist for a number of daily newspapers from NY to Texas.
    Visa customers in Sheffield report payment problems as company investigates 'service disruption'

    Visa customers in Sheffield report payment problems as company investigates 'service disruption'

    Several other institutional investors and hedge funds also recently made changes to their positions in the business. There is still some intermittency however, we believe this is due to a backlog of transactions", it said.
    Fortnite, Dragon Ball FighterZ And More Leaked For Nintendo Switch

    Fortnite, Dragon Ball FighterZ And More Leaked For Nintendo Switch

    It's possible they have no new first-party games to announce but again , they may just be playing it very close to the chest. Fortnite Switch's rating in Korea means that Epic Games has submitted an application to the country's rating board.
  • Serena Williams withdraws from French Open

    Serena Williams withdraws from French Open

    It's a Wimbledon final, you know? "I've never felt this in my life so I don't really know how to manage it yet", Williams said . It's been 14 years since Sharapova won against Williams and it has been 10 years since Sharapova took a set against Serena .
    ‘Holy Grail’ Blood Test May Detect Cancer Before Tumors Form

    ‘Holy Grail’ Blood Test May Detect Cancer Before Tumors Form

    It was less able to pick up stomach, uterine and early-stage low-grade prostate cancer. The tests found the cancers in four out of five patients who took it.
    LI homebuilder to the stars killed in Hamptons plane crash

    LI homebuilder to the stars killed in Hamptons plane crash

    Search efforts are continuing today for two people who remain missing after a deadly plane crash in the waters off Amagansett. The crash reportedly occurred during a storm that prevented the plane from staying in contact with an airport control tower.
  • Russia Invites North Korean Leader for Visit

    Russia Invites North Korean Leader for Visit

    The delicate balancing of USA needs and alliances with the promotion of human rights overseas has long bedeviled American leaders. He warned North Korea that only when they agree to complete denuclearization can they expect economic sanctions to lift.
    In 20 Page Letter, Trump Lawyers Tell Mueller POTUS Can't Obstruct Justice

    In 20 Page Letter, Trump Lawyers Tell Mueller POTUS Can't Obstruct Justice

    If Trump does not consent to an interview , Mueller will have to decide whether to go forward with a historic grand jury subpoena. Most of these items pertain to matters that, in my view, indeed can not be obstruction of justice, given the president's powers.
    German policeman shoots man at Berlin Cathedral

    German policeman shoots man at Berlin Cathedral

    The unnamed knifeman is a 53-year-old Austrian and appeared to be in a "confused state", according to reports. Video footage posted on social media showed armed policemen cordoning off the area around the cathedral.
  • Zverev avoids defeat as Dimitrov exits French Open

    Zverev avoids defeat as Dimitrov exits French Open

    Zverev was taken to five sets by Dusan Lajovic in the second round and saved match point against Damir Dzumhur in the third round. Zverev sank to his knees in celebration after defeating Khachanov in their first meeting on clay or at a major.
    IOS 12 wants you to spend less time on your faster iPhone

    IOS 12 wants you to spend less time on your faster iPhone

    Apple faced a backlash late previous year when it emerged that the company slowed down some older iPhones with flagging batteries. Also, anybody in the Group FaceTime will be able to customize how they appear, with different filters, Animoji or Memojis.
    'Frank' trade discussions in Beijing: US commerce secretary

    'Frank' trade discussions in Beijing: US commerce secretary

    Discussions centered on getting China to carry out recent promises to buy more American farm and energy products. China has also threatened to hit back with tit-for-tat tariffs on tens of billions of dollars in U.S. goods.